NUFOLD: END-TO-END APPROACH FOR RNA TERTIARY STRUCTURE PREDICTION WITH FLEXIBLE NUCLEOBASE CENTER REPRESENTATION

NuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation

Abstract RNA plays a crucial role not only in information transfer Paper Tray as messenger RNA during gene expression but also in various biological functions as non-coding RNAs.Understanding mechanical mechanisms of function needs tertiary structure information; however, experimental determination of three-dimensional RNA structures is costly and

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Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor Candle Holder (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop an acquired resistance.The treatment effect of EGFR-TKIs-resistant NSCLC patients still faces challenges.Cucurbitacin B (CuB), a triterpe

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Reviewing the Source, Physiological Characteristics, and Aroma Production Mechanisms of Aroma-Producing Yeasts

Flavor is an essential element of food quality.Flavor can be improved by adding flavoring substances or via microbial fermentation to impart aroma.Aroma-producing yeasts are a group of microorganisms that can produce aroma compounds, providing a strong aroma to foods and thus playing a great role in the modern fermentation industry.The physiologica

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Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations

Cannabinoids are emerging as promising treatments for inflammatory diseases such as ulcerative colitis.Specifically, cannabinoid 2 (CB2) receptors, which are upregulated during Paper Tray inflammation, have been distinctively linked to anti-inflammatory and analgesic effects.HU308, a synthetic cannabinoid developed to activate CB2 receptors selecti

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